diff --git a/build-constraints.yaml b/build-constraints.yaml
index ddd5d387..77c8b9a0 100644
--- a/build-constraints.yaml
+++ b/build-constraints.yaml
@@ -1894,7 +1894,7 @@ packages:
         - random-tree
         - clumpiness
         - find-clumpiness
-        - blosum
+        # - blosum # BLOCKED optparse-applicative https://github.com/GregorySchwartz/blosum/issues/2
 
     "Simon Marechal <bartavelle@gmail.com> @bartavelle":
         - compactmap